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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Von Willebrand factor type D domain ： ウィキペディア英語版 Von Willebrand factor type D domain In molecular biology, the protein domain Von Willebrand factor type D domain belongs to a large family of proteins, named, the von Willebrand factor (vWF). These proteins, the vWF type D domain in particular, is a large, multimeric glycoprotein and it is synthesized by a type of bone marrow cell called megakaryocytes. vWF type D plays 2 important roles in stopping the blood flow or loss of blood. Firstly, it causes platelets to adhere to the inside of the damaged blood vessel walls to prevent leakage of blood. Secondly, it is a as carrier protein for factor VIII (FVIII) which helps blood to clot. ==Function== One of the functions of von Willebrand factor (vWF) is to serve as a carrier of clotting factor VIII (FVIII). The native conformation of the D' domain of vWF is not only required for factor VIII (FVIII) binding but also for normal multimerisation and optimal secretion. The interaction between blood clotting factor VIII and VWF is necessary for normal survival of blood clotting factor VIII in blood circulation. The VWFD domain is a highly structured region, in which the first conserved Cys has been found to form a disulphide bridge with the second conserved one. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Von Willebrand factor type D domain」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.